Shank3 phosphorylation
Webb7 okt. 2011 · Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic … Webb16 nov. 2024 · Notably, murine SHANK3 is phosphorylated by MAPK1 at 18 residues, 3 of which have also been observed in vivo and shown to increase SHANK3 turnover and …
Shank3 phosphorylation
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WebbA bidirectional switch in the Shank3 phosphorylation state biases synapses toward up or down scaling Authors Chi-Hong Wu 1 , Vedakumar Tatavarty 1 , Pierre M J Beltran 2 , … Webb26 apr. 2024 · (F) Quantification of the density of synaptic puncta containing Shank3 phospho-mutants (number of neurons: WT, n = 32, AA, n = 30, DD, n = 24; Kruskal–Wallis test: p=0.2814). For imaging experiments here and below, each data point represents a single pyramidal neuron, and data were collected from at least four independent …
Webb7 okt. 2011 · Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. WebbThe SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD) (1), where they play a critical role in PSD assembly of excitatory synapses during development (2).
WebbGlycogen synthase kinase 3 (GSK3)-β (GSK3β) interaction protein (GSKIP) is one of the smallest A-kinase anchoring proteins that possesses a binding site for GSK3β. Webb22 maj 2024 · Shank3 is a highly phosphorylated protein Phosphorylation is one of the most common regulatory mechanisms to modulate synaptic protein interactions and subcellular localization. Since SHANK3 is a large essential scaffolding protein in the PSD, we sought to investigate phosphorylation-mediated SHANK3 regulation.
Webb3 okt. 2024 · Using a parallel proteomic analysis performed on Shank3 isolated from rat neocortical neurons by immunoaffinity, we identified two sites that were hypo-phosphorylated during scaling up and hyper-phosphorylated during scaling down: one (rat S1615) that corresponded to S1539 in mouse, and a second highly conserved site, rat …
WebbShank1 and Shank3 contain several RSK consensus phosphorylation sites (RXRXXS, where X is any amino acid) and both Shanks were efficiently phosphorylated by RSK2 in vitro (data not shown). Indeed, RSK2 phosphorylated Shank1 (368–932) with a K m value (0.17 μM) far below that for the S6 peptide (9.6 μM), a standard RSK2 in vitro substrate, … earth day at salisbury zooWebb7 apr. 2024 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12 ... ctf easy javaWebb16 aug. 2024 · Shank3 is essential for synaptic scaling up, as previously demonstrated by Turrigiano and her colleagues (Tatavarty et al., Neuron, 2024). In their recent study, they … earth day arts and crafts for preschoolersWebbShank3, a master postsynaptic scaffolding protein that controls the developmental maturation of excitatory synapses, was recently shown to be phosphorylated by Protein Kinase A (PKA) at Ser685 in vivo. earth day austin txWebbSummary Shank3 is an important scaffolding protein in the postsynaptic density (PSD). It functions in forming multiple complexes that anchor receptors, but also in connecting … earth day atxWebb26 mars 2024 · The synaptic scaffolding protein Shank3 binds CaMKII, ABI1, and many other proteins. We show that Ser685 in Shank3 can be phosphorylated by CaMKII or … earth day baby tvWebb26 mars 2024 · Shank3, a master postsynaptic scaffolding protein that controls the developmental maturation of excitatory synapses, was recently shown to be … ctf easy_node