Circnotch1
WebResults from various studies reveal that the role of G protein‐coupled oestrogen receptor (GPER) is cancer‐context dependent, and the function of GPER in non–small‐cell lung cancer (NSCLC) is still u... Webthis study, we showed that circNOTCH1 competed with NOTCH1 for the binding of methyltransferase like 14 (METTL14), decreasing NOTCH1 mRNA m6A methylation and …
Circnotch1
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WebShen Y et al. G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling. J Cell … WebNov 25, 2024 · G protein‐coupled oestrogen receptor promotes cell growth of non‐small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling - Shen …
WebFeb 1, 2024 · YAP1 is a core effector in the Hippo pathway and has been identified as a key regulator of tissue homeostasis and organ development [22], which can be phosphorylated and inactivated by Hippo... http://bjp.sagepub.unboundmedicine.com/medline/citation/31943342/miR_449c_5p_availability_is_antagonized_by_circ_NOTCH1_for_MYC_induced_NOTCH1_upregulation_as_well_as_tumor_metastasis_and_stemness_in_gastric_cancer_
WebSep 24, 2024 · Similar to other types of RNAs, circRNAs are involved in the maintenance of the normal physiological function of the human body, as well as the occurrence and development of a variety of human diseases [11–13]. While distinct from other RNA molecules, circRNAs possess unique biogenesis, biology, and characterization. WebShen Y et al. G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling. J Cell …
WebMar 1, 2024 · 1. Introduction. RNA modification is a vital post-transcriptional epigenetic modulator of eukaryotic gene expression, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and so on [1], [2].Among these RNA modifications, m6A is the most abundant and well-known type found to play an important …
WebDec 1, 2024 · Abstract. N 6 -methyladenosine (m 6A) is the most abundant and diverse epigenetic modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell differentiation and cycles, and responses to heat shock stress, cancers and other diseases. RNA methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14) and other ... how are people diagnosed with bipolarWebNov 25, 2024 · Further exploration of the mechanism demonstrated that GPER could up‐regulate circNOTCH1, which could compete with NOTCH1 mRNA for METTL14 binding. Because of the lack of m6A modification by METTL14 on the NOTCH1 mRNA, NOTCH1 mRNA was more stable and much easier to undergo protein translation. how many miles are brakes good forWebMechanistic dissection revealed that GPER could modulate the NOTCH1 pathway to regulate cell growth in NSCLC cells. Further exploration of the mechanism demonstrated … how are people diagnosed with schizophreniaWebMar 8, 2024 · Consistent with this finding, Shen et al. 68 found that circNOTCH1 can increase the expression of NOTCH1 by competitively binding with METTL14 in NSCLC. … how are people different from each otherWebApr 28, 2024 · ... nuclear receptor subfamily 4 group a member 1 (nr4a1) initiates notch2 signal activation to help maintain ilc3 homeostasis, which depends on m6a modification of Nr4a1 mrna by the highly... how are people elected in nzWebJan 14, 2024 · Subsequently, MYC was identified as a downstream gene of miR-449c-5p. MYC could bind to the promoter of NOTCH1 to regulate GC progression. Furthermore, rescue assays demonstrated that NOTCH1 knockdown reversed the effects of overexpression of MYC in metastasis and stemness in AGS cells/sh-circNOTCH1. how are people colorblindWebJan 29, 2024 · The C-terminal region of YTHDF2 recognizes specific m 6 A sites, and the N-terminal region binds to the SH domain of CCR4-NOT transcription complex subunit 1 (CNOT1), thus it could recruit the CCR4-NOT deadenylase complex and transport RNA to the processing body (P-body) to accelerate the degradation of m 6 A modified RNA. 56 … how are people dying from vapes